Ecological and observational studies suggest that low vitamin D status could be associated with higher mortality from life-threatening conditions including cancer, cardiovascular disease, and diabetes mellitus that account for 60% to 70% of total mortality in high-income countries. There has been resurgence in interest in vitamin D and its effect on bones and other diseases.
A new meta-analysis of 18 randomized controlled trials showed that individual who took vitamin D supplements had a 7% reduction in all-cause mortality. This meta-analysis covered 57311 participants, with 4777 deaths from all causes during size-adjusted mean of 5.7-years trial period. Daily doses of vitamin D supplements varied from 300 to 2000 IU with a mean daily vitamin D dose at 528 IU).
This study concluded that intake of ordinary doses of vitamin D supplements seems to be associated with decreases in total mortality rates. The relationship between baseline vitamin D status, dose of vitamin D supplements, and total mortality rates remains to be further investigated.
Article Source: Archives of Internal Medicine 2007; 167(16):1730-7.
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